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Hearty casserole dish with golden, fluffy biscuit layers topped with melted mozzarella and cheddar cheese, red pizza sauce, pepperoni slices, and green bell pepper bits, served in a rustic ceramic bowl on a wooden table with soft natural light.

Cheesy Biscuit Pizza Casserole

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A cozy, crowd-pleasing casserole that combines flaky biscuit layers with classic pizza toppings in one simple dish — perfect for weeknight dinners.

  • Total Time: 35 minutes
  • Yield: 6 servings

Ingredients

Scale
  • 2 cans (16.3 oz each) refrigerated biscuit dough
  • 1 ½ cups pizza sauce
  • 2 cups shredded mozzarella cheese
  • ½ cup grated Parmesan cheese
  • ½ cup sliced pepperoni
  • ¼ cup diced green bell pepper
  • 2 tbsp melted butter
  • ½ tsp garlic powder
  • Optional: cooked crumbled sausage or sliced black olives

Instructions

  1. Preheat oven to 375°F (190°C). Grease a 9×13-inch baking dish.
  2. Separate biscuit dough into individual biscuits; cut each into 4 pieces. Place half in the bottom of the dish.
  3. Spread pizza sauce over biscuits, then sprinkle with mozzarella, Parmesan, pepperoni, and bell peppers.
  4. Top with remaining biscuit pieces. Brush biscuit tops with melted butter mixed with garlic powder.
  5. Bake 20–25 minutes until biscuits are golden and cheese is bubbly. Let cool 5 minutes before serving.

Notes

  • For extra flavor, toss biscuit pieces in garlic butter before layering.
  • Use vegan cheese and plant-based pepperoni for a dairy-free or vegan option.
  • Leftovers reheat well in the oven or air fryer for a quick lunch.
  • Prep Time: 10 minutes
  • Cook Time: 25 minutes
  • Method: Baking
  • Cuisine: American
  • Diet: Contains Dairy, Gluten

Nutrition

  • Serving Size: 1/6 of casserole
  • Calories: 420 Kcal
  • Sugar: 4g
  • Sodium: 980mg
  • Fat: 26g
  • Saturated Fat: 12g
  • Unsaturated Fat: 13g
  • Trans Fat: 0.5g
  • Carbohydrates: 36g
  • Fiber: 2g
  • Protein: 16g
  • Cholesterol: 45mg
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