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A baked casserole dish with a golden-brown crust on top, filled with tender chicken pieces, vibrant green spinach, and creamy sauce. The dish is garnished with a sprinkle of grated cheese and fresh herbs, presented on a rustic wooden table with steam rising, highlighting its comforting appeal.

45-Minute Creamy Chicken and Spinach Casserole

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Discover the delicious and hearty 45-Minute Creamy Chicken and Spinach Casserole, a quick and nutritious dinner perfect for busy weeknights. This flavorful casserole features tender chicken, fresh spinach, and a rich, creamy sauce, all ready in just 45 minutes. Ideal for family meals, it combines wholesome ingredients with simple preparation for a satisfying dish that everyone will love.

  • Total Time: 45 minutes
  • Yield: 4-6 servings 1x

Ingredients

Scale
  • 2 lbs chicken breasts, diced
  • 2 cups fresh spinach, chopped
  • 1 cup shredded cheese (cheddar, mozzarella, or a blend)
  • 1 can cream of mushroom soup (or homemade creamy sauce)
  • 1/2 cup sour cream
  • 3 cloves garlic, minced
  • 1 teaspoon Italian seasoning
  • Salt and pepper to taste
  • 2 tablespoons olive oil
  • Optional: crushed red pepper flakes for a kick

Instructions

  1. Heat a quality skillet or non-stick pan with olive oil and cook the diced chicken over medium heat until golden brown and cooked through. Season with salt, pepper, and Italian seasoning. Once cooked, set aside.
  2. In the same pan, add garlic and sauté until fragrant. Stir in the cream of mushroom soup, sour cream, and a little water or broth if needed to achieve the desired consistency. Let it simmer for a few minutes, allowing flavors to meld.
  3. Add the cooked chicken and chopped spinach to the sauce. Mix well until the spinach begins to wilt. Adjust seasoning as needed.
  4. Transfer the mixture to a greased baking dish. Top with shredded cheese and bake in a preheated oven at 375°F (190°C) for about 15-20 minutes, or until bubbly and golden on top.

Notes

  • Let the casserole cool completely before transferring to an airtight container. Store in the refrigerator for up to 3 days. Reheat in the microwave or oven at 350°F until heated through. For longer storage, freeze portions for up to 2 months.
  • For added flavor, sprinkle crushed red pepper flakes or additional cheese before baking.
  • Author: Serena Miller
  • Prep Time: 10 minutes
  • Cook Time: 35 minutes
  • Category: Dinner
  • Method: Baking, Sautéing
  • Cuisine: American
  • Diet: Low-Carb (with modifications)

Nutrition

  • Serving Size: 1 bowl
  • Calories: 420 Kcal
  • Sugar: 4g
  • Sodium: 750mg
  • Fat: 25g
  • Saturated Fat: 12g
  • Unsaturated Fat: 10g
  • Trans Fat: 0g
  • Carbohydrates: 12g
  • Fiber: 3g
  • Protein: 45g
  • Cholesterol: 125mg